Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Wasf2tm1Fwa
Name:	WASP family, member 2; targeted mutation 1, Frederick W Alt
MGI ID:	MGI:2670143
Synonyms:	WAVE2neo
Gene:	Wasf2  Location: Chr4:132857843-132927067 bp, + strand  Genetic Position: Chr4, 66.22 cM
Alliance:	Wasf2tm1Fwa page

Germline Transmission:	Earliest citation of germline transmission: J:84642
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A sequence fragment encompassing exons 3 through 7 was replaced with a cassette containing floxed neo followed by IRES-GFP. Northern and Western blot analyses of homozygous mutant ES cells indicated an absence of normal transcript and protein. (J:84642)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wasf2 Mutation:	119 strains or lines available

Original:	J:84642 Yan C, et al., WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J. 2003 Jul 15;22(14):3602-12
All:	1 reference(s)