Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Runx1tm2Spe
Name:	runt related transcription factor 1; targeted mutation 2, Nancy A Speck
MGI ID:	MGI:2668479
Synonyms:	Cbfa2lz, Runx1lacZ, Runx1:lacZ, Runx1-LacZ KI, Runx1lz
Gene:	Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance:	Runx1tm2Spe page

Germline Transmission:	Earliest citation of germline transmission: J:56184
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A 10kb segment including exons 7 and 8 (but not the splice acceptor site of exon 7) was replaced with lacZ coding sequence followed by a PGK-neomycin resistance gene. A fusion protein is produced which contains the N-terminal 242 amino acids of Runx1, including its nuclear localization sequences, combined with beta-galactosidase sequences. The fusion protein lacks Runx1 function. (J:56184)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	296 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:	35 strains or lines available

Original:	J:56184 North T, et al., Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. Development. 1999 Jun;126(11):2563-75
All:	30 reference(s)