Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(PAH-INSR)1Rjv
Name:	transgene insertion 1, Rajiv L Joshi
MGI ID:	MGI:2665339
Synonyms:	PAH-IRdelta
Transgene:	Tg(PAH-INSR)1Rjv  Location: unknown
Alliance:	Tg(PAH-INSR)1Rjv page

Strain of Origin:

(C57BL/6 x CBA)F1

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(PAH-INSR)1Rjv expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human INSR (3643) Insr  (MGI:96575)   Mutation details: The transgene consists of a human PAH promoter and a sequence endcoding a truncated and activated from of human INSR. The mutant INSR contains the first 12 amino acids of the alpha subunit fused to 20% of the C-terminal portion of the alpha subunit and the entire beta subunit. Strong transgene expression in the liver (approximately 6.5-fold higher than endogenous mouse mRNA) was confirmed by RT-PCR and Western blot. Weak transgene expression was also observed in kidneys and testis. (J:80773)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:80773 Baudry A, et al., Partial rescue of insulin receptor-deficient mice by transgenic complementation with an activated insulin receptor in the liver. Gene. 2002 Oct 16;299(1-2):219-25
All:	1 reference(s)