Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atp1a2tm1Kwk
Name:	ATPase, Na+/K+ transporting, alpha 2 polypeptide; targeted mutation 1, Kiyoshi Kawakami
MGI ID:	MGI:2664907
Synonyms:	Atp1a2-, Atp1a2tmCKwk, C-KO
Gene:	Atp1a2  Location: Chr1:172099276-172125631 bp, - strand  Genetic Position: Chr1, 79.6 cM
Alliance:	Atp1a2tm1Kwk page

Germline Transmission:	Earliest citation of germline transmission: J:83884
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A PGKneobpA cassette was inserted in exon 21. Lack of gene transcription in the brain was established by Northern blotting and the absence of protein in brain microsomal fractions of homozygous E18.5 embryos was then established on Western blots. (J:83884)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp1a2 Mutation:	61 strains or lines available

Original:	J:83884 Ikeda K, et al., Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump alpha2 subunit (Atp1a2)-deficient mice. J Neurosci. 2003 Jun 1;23(11):4667-76
All:	4 reference(s)