Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcl11atm1Ngc
Name:	BCL11 transcription factor A; targeted mutation 1, Neal G Copeland
MGI ID:	MGI:2663941
Gene:	Bcl11a  Location: Chr11:24028056-24124123 bp, + strand  Genetic Position: Chr11, 14.41 cM
Alliance:	Bcl11atm1Ngc page

Germline Transmission:	Earliest citation of germline transmission: J:83646
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 2.4 kb region containing exon 1 was deleted and replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Northern blot and immunohistochemical analysis of homozygous mutant brains. (J:83646)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl11a Mutation:	42 strains or lines available

Original:	J:83646 Liu P, et al., Bcl11a is essential for normal lymphoid development. Nat Immunol. 2003 Jun;4(6):525-32
All:	6 reference(s)