Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Notch2tm1.1Hhi
Name:	notch 2; targeted mutation 1.1, Hisamaru Hirai
MGI ID:	MGI:2663710
Synonyms:	Notch2f, Notch2tm1Hhi
Gene:	Notch2  Location: Chr3:97920854-98057683 bp, + strand  Genetic Position: Chr3, 42.42 cM
Alliance:	Notch2tm1.1Hhi page

Germline Transmission:	Earliest citation of germline transmission: J:83476
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Flanking loxP sites and a PGK-neo cassette were introduced to the exons encoding the transmembrane domains. The selection cassette was subsequently deleted by transient expression of cre recombinase in correctly targeted ES cells, leaving loxP sites flanking the sequences encoding the transmembrane domain. (J:83476)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Notch2 Mutation:	97 strains or lines available

Original:	J:83476 Saito T, et al., Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity. 2003 May;18(5):675-85
All:	13 reference(s)