Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Thpotm1Mwm
Name:	thrombopoietin; targeted mutation 1, Mark W Moore
MGI ID:	MGI:2662551
Synonyms:	TPO-
Gene:	Thpo  Location: Chr16:20543204-20553261 bp, - strand  Genetic Position: Chr16, 12.51 cM
Alliance:	Thpotm1Mwm page

Germline Transmission:	Earliest citation of germline transmission: J:83262
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The targeting construct introduces a neo cassette into the 4th exon of the gene, replacing sequences encoding 23 amino acids in the domain responsible for receptor binding and activation. mRNA was not detected in the liver and kidney of mutant animals. (J:83262)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thpo Mutation:	22 strains or lines available

Original:	J:83262 de Sauvage FJ, et al., Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med. 1996 Feb 1;183(2):651-6
All:	20 reference(s)