Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gfi1tm1Tmo
Name:	growth factor independent 1 transcription repressor; targeted mutation 1, Tarik Moroy
MGI ID:	MGI:2660761
Synonyms:	Gfi1Deltaex2-5
Gene:	Gfi1  Location: Chr5:107864521-107873671 bp, - strand  Genetic Position: Chr5, 52.23 cM
Alliance:	Gfi1tm1Tmo page

Germline Transmission:	Earliest citation of germline transmission: J:75143
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exons 2-4, and part of exon 5, with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of thymus proteins. (J:75143)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gfi1 Mutation:	31 strains or lines available

Original:	J:75143 Karsunky H, et al., Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nat Genet. 2002 Mar;30(3):295-300
All:	27 reference(s)