Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il4ratm1Fbb
Name:	interleukin 4 receptor, alpha; targeted mutation 1, Frank Brombacher
MGI ID:	MGI:2657172
Synonyms:	IL-4R-, il4ra-, IL-4Ralpha-, IL-4Ralpha KO
Gene:	Il4ra  Location: Chr7:125151443-125178646 bp, + strand  Genetic Position: Chr7, 68.94 cM
Alliance:	Il4ratm1Fbb page

Germline Transmission:	Earliest citation of germline transmission: J:55526
Parent Cell Line:	BALB/c-I (ES Cell)
Strain of Origin:	BALB/cJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 7 through 9 were replaced with a single loxP site after homologous recombination and cre-mediate excision. The deleted region encoded the transmembrane, the soluble, and extracelluar membrane proximal regions. FACS analysis and assays of sera indicated a lack of an appreciable amount of both membrane-bound and soluble protein in homozygous mutant mice. (J:55526)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il4ra Mutation:	41 strains or lines available

Original:	J:55526 Mohrs M, et al., Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling. J Immunol. 1999 Jun 15;162(12):7302-8
All:	112 reference(s)