Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ntrk3tm1Kln
Name:	neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 1, Rudiger Klein
MGI ID:	MGI:2656335
Synonyms:	trkCshc
Gene:	Ntrk3  Location: Chr7:77825711-78228865 bp, - strand  Genetic Position: Chr7, 44.01 cM
Alliance:	Ntrk3tm1Kln page

Germline Transmission:	Earliest citation of germline transmission: J:75365
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Not Specified) Mutation:    Nucleotide substitutions   Mutation details: A tyrosine to phenylalanine substitution was introduced at residue 516 (Y516F) of the Shc adaptor binding site and a floxed neo cassette was inserted into the upstream intron via homologous recombination. The neo cassette was removed by mating mutant animals to cre deleter line TgN(CMV-cre)1Cgn. (J:75365)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntrk3 Mutation:	65 strains or lines available

Original:	J:75365 Postigo A, et al., Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons. Genes Dev. 2002 Mar 1;16(5):633-45
All:	1 reference(s)