Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Epas1tm1Yfk
Name:	endothelial PAS domain protein 1; targeted mutation 1, Yoshiaki Fujii-Kuriyama
MGI ID:	MGI:2653011
Synonyms:	HLFkd
Gene:	Epas1  Location: Chr17:87061292-87140838 bp, + strand  Genetic Position: Chr17, 56.9 cM
Alliance:	Epas1tm1Yfk page

Germline Transmission:	Earliest citation of germline transmission: J:82257
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Hypomorph) Mutation:    Insertion   Mutation details: The 5' UTR was disrupted by the insertion of a floxed PGK-neo cassette into exon 1 by homologous recombination. Real-time quantitative PCR analsysis of homozygous mutant mice showed reduced levels of transcript ranging from 20% to 80% of wild-type levels, depending on the organ. (J:82257)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epas1 Mutation:	64 strains or lines available

Original:	J:82257 Morita M, et al., HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J. 2003 Mar 3;22(5):1134-46
All:	4 reference(s)