Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nr3c1tm1Ljm
Name:	nuclear receptor subfamily 3, group C, member 1; targeted mutation 1, Louis J Muglia
MGI ID:	MGI:2651864
Synonyms:	GRko, GRnull
Gene:	Nr3c1  Location: Chr18:39543598-39652474 bp, - strand  Genetic Position: Chr18, 21.09 cM
Alliance:	Nr3c1tm1Ljm page

Germline Transmission:	Earliest citation of germline transmission: J:82174
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 1C and 2 were deleted via homologous recombination followed by in vitro cre mediated recombination. Protein was undetected by Western blot analysis of homozygous mutant liver tissue. (J:82174)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:	34 strains or lines available

Original:	J:82174 Brewer JA, et al., Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J Immunol. 2002 Aug 15;169(4):1837-43
All:	4 reference(s)