Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pigrtm1Fejo
Name:	polymeric immunoglobulin receptor; targeted mutation 1, Finn-Eirik Johansen
MGI ID:	MGI:2651657
Synonyms:	pIgR-
Gene:	Pigr  Location: Chr1:130754421-130779986 bp, + strand  Genetic Position: Chr1, 56.89 cM, cytoband E3
Alliance:	Pigrtm1Fejo page

Germline Transmission:	Earliest citation of germline transmission: J:57987
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 3, which encodes the ligand binding extracellular receptor domain 1 (D1), was disrupted by a neomycin selection cassette inserted by homologous recombination. Two aberrant transcripts were identified in homozygous mutant mice by Northern blot analysis. Both transcripts lacked sequence encoding the extracellular binding domain and were not expected to bind the endogenous ligand. This targeting vector was also electroporated into ES cells derived from a C57BL/6 background to generated Pigrtm1Rast. (J:57987)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pigr Mutation:	59 strains or lines available

Original:	J:57987 Johansen FE, et al., Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice. J Exp Med. 1999 Oct 4;190(7):915-22
All:	17 reference(s)