Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atp1a2tm2Ling
Name:	ATPase, Na+/K+ transporting, alpha 2 polypeptide; targeted mutation 2, Jerry B Lingrel
MGI ID:	MGI:2451291
Synonyms:	alpha2-
Gene:	Atp1a2  Location: Chr1:172099276-172125631 bp, - strand  Genetic Position: Chr1, 79.6 cM
Alliance:	Atp1a2tm2Ling page

Germline Transmission:	Earliest citation of germline transmission: J:55191
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The insertion of an hprt cassette into exon 4 resulted in an alpha 2 isoform specific disruption. Both alpha 2 transcript and protein levels were reduced by ~50% in heterozygous mutant hearts. An aberrant alpha 2 transcript was detected but was not expected to produce a functional protein. (J:55191)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	39 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp1a2 Mutation:	61 strains or lines available

Original:	J:55191 James PF, et al., Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart. Mol Cell. 1999 May;3(5):555-63
All:	13 reference(s)