Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hba-a1tm1Shs
Name:	hemoglobin alpha, adult chain 1; targeted mutation 1, Takuji Shirasawa
MGI ID:	MGI:2451238
Synonyms:	alphaTitu
Gene:	Hba-a1  Location: Chr11:32233672-32234486 bp, + strand  Genetic Position: Chr11, 18.86 cM
Alliance:	Hba-a1tm1Shs page

Germline Transmission:	Earliest citation of germline transmission: J:81902
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Humanized sequence) Mutations:    Insertion, Single point mutation   Mutation details: A transition point mutation was introduced at codon 94 via site directed mutagenesis, resulting in an Asp to Asn substitution (D94N) at the alpha/beta interface of the hemoglobin molecule. An intronic floxed neo cassette was included downstream of the coding region. (J:81902)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hba-a1 Mutation:	3 strains or lines available

Original:	J:81902 Shirasawa T, et al., Oxygen affinity of hemoglobin regulates O2 consumption, metabolism, and physical activity. J Biol Chem. 2003 Feb 14;278(7):5035-43
All:	1 reference(s)