Lipatm1Ggb
Targeted Allele Detail
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Symbol: |
Lipatm1Ggb |
Name: |
lysosomal acid lipase A; targeted mutation 1, Gregory A Grabowski |
MGI ID: |
MGI:2451080 |
Synonyms: |
lal- |
Gene: |
Lipa Location: Chr19:34469718-34504874 bp, - strand Genetic Position: Chr19, 29.7 cM
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Alliance: |
Lipatm1Ggb page
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Lipid storage in the liver and small intestine and decrease in subcutaneous white adipose tissue in Lipatm1Ggb/Lipatm1Ggb mice as they age
Show the 5 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:49674
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The gene was disrupted by replacement of exon 5 with an HPRT cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern and Western blot analysis of liver homogenates.
(J:49674)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lipa Mutation: |
21 strains or lines available
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Original: |
J:49674 Du H, et al., Targeted disruption of the mouse lysosomal acid lipase gene: long-term survival with massive cholesteryl ester and triglyceride storage. Hum Mol Genet. 1998 Sep;7(9):1347-54 |
All: |
32 reference(s) |
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