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HrTg5053Mm
Transgenic Allele Detail
Summary
Symbol: HrTg5053Mm
Name: lysine demethylase and nuclear receptor corepressor; transgene insertion 5053, Miriam Meisler
MGI ID: MGI:1858045
Synonyms: hrTgN5053Mm
Gene: Hr  Location: Chr14:70789652-70810988 bp, + strand  Genetic Position: Chr14, 36.32 cM
Alliance: HrTg5053Mm page
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H/He)F2
Transgene
description
Transgene Type:    Transgenic
Mutation:    Insertion
 
Mutation details: This allele was initially defined by a noncomplementation test with hr and subsequently found to be the result of the integration of a 2 kb construct, M2CAT ,containing an amylase/elastase enhancer/promoter, between intron 5 and exon 8 of the hairless gene, and deletion of the 3-prime portion of the gene (J:15642, J:57947)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hr Mutation:  84 strains or lines available
Notes
PCR analysis of flanking markers suggest that the transgene insertion site occurred in the C57BL/6J parent. This allele of Hr was induced by transgenic insertion of a construct with an amylase/elastase enhancer/promotor directing expression of the bacterial chloramphenicolacetyl transferase reporter gene. The clinical and histological phenotype of this mutant closely resembles the phenotype of rhino allele mutants (J:15642).
References
Original:  J:15642 Jones JM, et al., Insertional mutation of the hairless locus on mouse chromosome 14. Mamm Genome. 1993 Nov;4(11):639-43
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
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