Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Egr4tm1Jmi
Name:	early growth response 4; targeted mutation 1, Jeffrey Milbrandt
MGI ID:	MGI:2450146
Gene:	Egr4  Location: Chr6:85488103-85490571 bp, - strand  Genetic Position: Chr6, 37.48 cM
Alliance:	Egr4tm1Jmi page

Germline Transmission:	Earliest citation of germline transmission: J:58099
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The insertion of a neomycin selection cassette deleted a portion of the zinc finger binding domain and precluded the translation of downstream amino acids. While normal transcript was undetected by Northern blot analysis of homozygous mutant brain and testis tissue, low levels of a transcript encoding 5' amino acids and a portion of neo was observed. (J:58099)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Egr4 Mutation:	13 strains or lines available

Original:	J:58099 Tourtellotte WG, et al., Infertility associated with incomplete spermatogenic arrest and oligozoospermia in Egr4-deficient mice. Development. 1999 Nov;126(22):5061-71
All:	4 reference(s)