Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Apctm3Mmt
Name:	APC, WNT signaling pathway regulator; targeted mutation 3, Makoto M Taketo
MGI ID:	MGI:2449944
Synonyms:	ApcneoR
Gene:	Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Alliance:	Apctm3Mmt page

Germline Transmission:	Earliest citation of germline transmission: J:81402
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, Hypomorph) Mutation:    Insertion   Mutation details: LoxP sites flanking exons 11-13 were introduced and a neomycin resistance gene was inserted downstream of exon 13 in the direction opposite of transcription. RT-PCR analysis of heterozygous and homozygous mutant animals showed reduced gene expression at approximately 55% and 20% that of wild-type, respectively. This is a hypomorphic allele. (J:81402)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	29 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:	154 strains or lines available

Original:	J:81402 Ishikawa TO, et al., Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo. Dev Biol. 2003 Jan 15;253(2):230-46
All:	3 reference(s)