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Tll1tm1Dgr
Targeted Allele Detail
Summary
Symbol: Tll1tm1Dgr
Name: tolloid-like; targeted mutation 1, Daniel S Greenspan
MGI ID: MGI:2449853
Synonyms: Tll1-/-
Gene: Tll1  Location: Chr8:64467965-64659305 bp, - strand  Genetic Position: Chr8, 32.19 cM
Alliance: Tll1tm1Dgr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54910
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 6, which encodes the zinc-binding active site, with a neomycin resistance gene resulting in a frameshift mutation and premature stop codon. RT-PCR analysis of RNA from whole homozygous mutant embryos at day E13.5 confirmed the absence of gene expression. (J:54910)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tll1 Mutation:  69 strains or lines available
References
Original:  J:54910 Clark TG, et al., The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart. Development. 1999 Jun;126(12):2631-42
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory