Hprt1tm1(AGT)Sig
Targeted Allele Detail
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| Symbol: |
Hprt1tm1(AGT)Sig |
| Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Curt Sigmund |
| MGI ID: |
MGI:2449451 |
| Synonyms: |
hAGTAT |
| Gene: |
Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
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| Alliance: |
Hprt1tm1(AGT)Sig page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:81310
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| Parent Cell Line: |
BK4 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Hprt1tm1(AGT)Sig expresses
1 gene
Knock-in expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
AGT (183) |
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Mutation details: The entire human AGT genomic sequence containing an A to G nucleotide substitution at position -6 of the promoter was inserted into the Hprt locus via homologous recombination. (This polymorphism has been reported in association with hypertension in humans.) RNase protection assay showed transgene expression in liver, kidneys, brain, and aorta. In addition, immunohistochemical analysis and Western blot detected transgene expression in the kidneys and plasma, respectively.
(J:81310)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Hprt1 Mutation: |
1273 strains or lines available
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| Original: |
J:81310 Cvetkovic B, et al., Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse. Physiol Genomics. 2002 Dec 3;11(3):253-62 |
| All: |
2 reference(s) |
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Analysis Tools
