Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pck1tm1Mgn
Name:	phosphoenolpyruvate carboxykinase 1, cytosolic; targeted mutation 1, Mark A Magnuson
MGI ID:	MGI:2449282
Synonyms:	pcklox+neo
Gene:	Pck1  Location: Chr2:172994866-173001067 bp, + strand  Genetic Position: Chr2, 95.79 cM, cytoband C1-qter
Alliance:	Pck1tm1Mgn page

Germline Transmission:	Earliest citation of germline transmission: J:63929
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, Hypomorph) Mutation:    Insertion   Mutation details: A loxP-flanked neomycin selection cassette was inserted into intron 3 and a single loxP site was inserted into intron 5. Activity and protein mass assays on protein derived from kidney and liver of fasted homozygous mice demonstrated that this allele behaves as a hypomorph, retaining about 10-20% of normal activity. (J:63929)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pck1 Mutation:	47 strains or lines available

Original:	J:63929 She P, et al., Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol Cell Biol. 2000 Sep;20(17):6508-17
All:	2 reference(s)