Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plcg2tm1Kuro
Name:	phospholipase C, gamma 2; targeted mutation 1, Tomohiro Kurosaki
MGI ID:	MGI:2449276
Synonyms:	PLC-gamma2flox, PLCgamma2flox
Gene:	Plcg2  Location: Chr8:118225030-118361881 bp, + strand  Genetic Position: Chr8, 64.26 cM
Alliance:	Plcg2tm1Kuro page

Germline Transmission:	Earliest citation of germline transmission: J:63744
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A single loxP site and a loxP-flanked neomycin selection cassette were inserted to flank the exon encoding the PIP-2 binding site. The neomycin selection cassette was removed by transient Cre expression in ES cells prior to the production of mice, leaving a single loxP element at the insertion site. (J:63744)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plcg2 Mutation:	74 strains or lines available

Original:	J:63744 Hashimoto A, et al., Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function. J Immunol. 2000 Aug 15;165(4):1738-42
All:	8 reference(s)