Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nkx2-5tm2(cre)Rph
Name:	NK2 homeobox 5; targeted mutation 2, Richard P Harvey
MGI ID:	MGI:2448972
Synonyms:	Nkx2.5-Cre, Nkx2-5IRESCre
Gene:	Nkx2-5  Location: Chr17:27057638-27063962 bp, - strand  Genetic Position: Chr17, 13.6 cM
Alliance:	Nkx2-5tm2(cre)Rph page

Germline Transmission:	Earliest citation of germline transmission: J:80725
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (No functional change, Recombinase) Mutation:    Insertion   Nkx2-5tm2(cre)Rph expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Nkx2-5 (MGI:97350)   Mutation details: Sequence encoding cre recombinase adjoined to an IRES was inserted into the 3' UTR of the endogenous locus via homologous recombination. A single frt site remained in the UTR after an frt-flanked hygromycin selection cassette was excised. A lack of observed allele complementation indicated that the inserted sequence did not significantly affect expression of the endogenous locus. (J:80725)

Generation of the Smyd2tm1.1Fben allele

Activity:	Tissue activity of this recombinase allele
Driver:	Nkx2-5 (mouse) Summary of all recombinase alleles driven by Nkx2-5. Comparative matrix view of recombinase activities Alliance mouse Nkx2-5 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	68 assay results 11 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkx2-5 Mutation:	21 strains or lines available

Original:	J:80725 Stanley EG, et al., Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int J Dev Biol. 2002;46(4):431-9
All:	72 reference(s)