Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sox2lcc
Name:	SRY (sex determining region Y)-box 2; light coat and circling
MGI ID:	MGI:2447995
Synonyms:	In(3)9H
Gene:	Sox2  Location: Chr3:34704554-34706610 bp, + strand  Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Alliance:	Sox2lcc page

Strain of Origin:

C3H/HeH x 101/H

Allele Type:    Radiation induced Mutation:    Inversion   Sox2lcc involves 205 genes/genome features (Gm26678, Exosc9, Ccna2 ...) View all   Mutation details: A mutation recovered in a radiation mutagenesis experiment. Molecular analysis revealed an inversion with breakpoints at B and E1. Genetic noncomplementation tests with a targeted mutation indicated that this mutation is an allele of Sox2. Genomic PCR analysis showed that the coding region and nearby flanking DNA was intact in the mutants. Expression of the gene was intact in most of the developing neural tube but was not detected in the otocyst or adjacent region of the hindbrain, in contrast to controls. This tissue specific loss is thought to be due to loss or translocation of tissue-specific regulatory elements. (J:98458) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sox2 Mutation:	56 strains or lines available

Original:	J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
All:	5 reference(s)