Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grm1tm1Stl
Name:	glutamate receptor, metabotropic 1; targeted mutation 1, Susumu Tonegawa
MGI ID:	MGI:1857987
Synonyms:	mGluR1-
Gene:	Grm1  Location: Chr10:10561803-10958100 bp, - strand  Genetic Position: Chr10, 3.44 cM, cytoband A2
Alliance:	Grm1tm1Stl page

Germline Transmission:	Earliest citation of germline transmission: J:21086
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced 2.1kb of the gene, including the 3' portion of exon 1 that encodes amino acids 1 - 233 of the protein. Northern blots of total RNA from cerebella of homozygous mutant mice showed no detectable transcripts of the targeted gene. Western blots of extracts of the cerebella of homozygous mutant mice showed no detectable protein. (J:21086)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grm1 Mutation:	78 strains or lines available

Original:	J:21086 Aiba A, et al., Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell. 1994 Oct 21;79(2):365-75
All:	20 reference(s)