Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Smarcb1tm3Sho
Name:	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1; targeted mutation 3, Stuart Orkin
MGI ID:	MGI:2447708
Synonyms:	Snf5inv
Gene:	Smarcb1  Location: Chr10:75732603-75757448 bp, - strand  Genetic Position: Chr10, 38.61 cM
Alliance:	Smarcb1tm3Sho page

Germline Transmission:	Earliest citation of germline transmission: J:80224
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP-flanked neomycin selection cassette was inserted into intron 1 and a single loxP site in the opposite orientation was inserted 0.8 kb upstream of exon 1. The neomycin selection cassette was removed by transient Cre expression in ES cells, leaving oppositely oriented loxP sites flanking exon 1 in the final allele. Upon Cre-mediated recombination, exon 1 and flanking sequences are inverted in orientation with respect to the rest of the gene. (J:80224)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

List all tumor models in MMHCdb carrying Smarcb1tm3Sho

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smarcb1 Mutation:	22 strains or lines available

Original:	J:80224 Roberts CW, et al., Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer Cell. 2002 Nov;2(5):415-25
All:	4 reference(s)