Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grm7tm1Nak
Name:	glutamate receptor, metabotropic 7; targeted mutation 1, Shigetada Nakanishi
MGI ID:	MGI:1857984
Synonyms:	Grm7tmNovartis, mGluR7-, mGluR7 KO
Gene:	Grm7  Location: Chr6:110622542-111544191 bp, + strand  Genetic Position: Chr6, 51.19 cM
Alliance:	Grm7tm1Nak page

Germline Transmission:	Earliest citation of germline transmission: J:52411
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a part of the first coding exon comprising the 5' untranslated region and the first 164 amino acids of the protein. In situ hybridization of sagittal and coronal sections of the brain using an antisense probe corresponding to the first coding exon of the targeted gene showed no detectable mRNA expression in homozygous mutant mice. (J:52411)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grm7 Mutation:	124 strains or lines available

Original:	J:52411 Masugi M, et al., Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion. J Neurosci. 1999 Feb 1;19(3):955-63
All:	12 reference(s)