Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Snai2tm1Look
Name:	snail family zinc finger 2; targeted mutation 1, A Thomas Look
MGI ID:	MGI:2447174
Synonyms:	Slug-/-
Gene:	Snai2  Location: Chr16:14523716-14527249 bp, + strand  Genetic Position: Chr16, 10.07 cM
Alliance:	Snai2tm1Look page

Germline Transmission:	Earliest citation of germline transmission: J:80652
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.2 kb region of the gene encompassing exon 1 and part of exon 2 was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis of mouse embryonic fibroblasts derived from homozygous mutant embryos confirmed the absence of gene expression. (J:80652)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snai2 Mutation:	34 strains or lines available

Original:	J:80652 Inoue A, et al., Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell. 2002 Oct;2(4):279-88
All:	3 reference(s)