Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sox5tm1Vlf
Name:	SRY (sex determining region Y)-box 5; targeted mutation 1, Veronique Lefebvre
MGI ID:	MGI:2447147
Gene:	Sox5  Location: Chr6:143774151-144727703 bp, - strand  Genetic Position: Chr6, 76.14 cM
Alliance:	Sox5tm1Vlf page

Germline Transmission:	Earliest citation of germline transmission: J:80666
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a lacZ-neo-derived cassette into the fifth coding exon of the gene corresponding to the N terminus of the coiled coil domain. Absence of gene expression in homozygous animals was confirmed by Northern blot analysis of whole embryo RNA. X-gal staining of mutant embryos revealed lacZ expression in cartilage tissue. (J:80666)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox5 Mutation:	44 strains or lines available

Original:	J:80666 Smits P, et al., The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell. 2001 Aug;1(2):277-90
All:	10 reference(s)