Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Camk2a-Fyn)1Kndl
Name:	transgene insertion 1, Eric R Kandel
MGI ID:	MGI:2446639
Synonyms:	N8
Transgene:	Tg(Camk2a-Fyn)1Kndl  Location: unknown
Alliance:	Tg(Camk2a-Fyn)1Kndl page

Strain of Origin:

(C57BL/6 x CBA)F1

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Camk2a-Fyn)1Kndl expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Fyn (MGI:95602) Expresses Fyn (isoform B) cDNA   Tg(Camk2a-Fyn)1Kndl expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Camk2a (MGI:88256)   Mutation details: An Fyn (isoform B) cDNA and Camk2a promoter were used for the transgene. Transgene expression was confirmed in the forebrain of 1-month old transgenic animals by Northern blot and in situ hybridization. Transgenic RNA is expressed at 4 times the level of endogenous Fyn RNA. 8 kb of Camk2a promoter sequences directs transgene expression in postnatal forebrain neurons. (J:80637)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:80637 Kojima N, et al., Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4761-5
All:	13 reference(s)