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Pik3cdtm1Jni
Targeted Allele Detail
Nomenclature
Symbol: Pik3cdtm1Jni
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; targeted mutation 1, James N Ihle
MGI ID: MGI:2446574
Synonyms: p110delta-, PI3Kdelta-
Gene: Pik3cd  Location: Chr4:149649168-149702566 bp, - strand  Genetic Position: Chr4, 80.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80614
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.6 kb fragment extending from within exon 2 through exon 6 was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis of splenic lysates indicated an absence of endogenous protein in homozygous mutant mice. (J:80614)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3cd Mutation:  13 strains or lines available
References
Original:  J:80614 Jou ST, et al., Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110delta in Signaling by the B-Cell Receptor Complex. Mol Cell Biol. 2002 Dec;22(24):8580-91
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory