Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Terctm1Rdp Name: telomerase RNA component; targeted mutation 1, Ronald DePinho MGI ID: MGI:1857930 Synonyms: mTerc-, mTR-, Terc-, TR- Gene: Terc  Location: Chr3:96321753-96322149 bp, - strand  Genetic Position: Chr3, 41.82 cM, cytoband F/G Alliance: Terctm1Rdp page

Axial/lateral elements of synaptonemal complexes and apoptosis of seminiferous tubules in Terctm1Rdp/Terctm1Rdp mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:43517
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Replacement of the entire gene with a neomycin cassette. (J:43517)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	19 anatomical structure(s)

List all tumor models in MMHCdb carrying Terctm1Rdp

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Terc Mutation:	8 strains or lines available

Original:	J:43517 Blasco MA, et al., Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 1997 Oct 3;91(1):25-34
All:	189 reference(s)