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Targeted Allele Detail
Symbol: Tfcp2tm1Jmc
Name: transcription factor CP2; targeted mutation 1, John M Cunningham
MGI ID: MGI:2445840
Gene: Tfcp2  Location: Chr15:100395893-100449889 bp, - strand  Genetic Position: Chr15, 56.33 cM
Germline Transmission:  Earliest citation of germline transmission: J:67993
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 1 and all of exon 2 was replaced by a hygromycin selection cassette inserted by homologous recombination. The insertion deleted sequence encoding the initiator methionine and the trans-activation domain and introduced a frameshift mutation into all reading frames. Transcript was undetected by both RNAse protection and RT-PCR analysis. (J:67993)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tfcp2 Mutation:  16 strains or lines available
ES cell line = RW8.
Original:  J:67993 Ramamurthy L, et al., Targeted disruption of the CP2 gene, a member of the NTF family of transcription factors. J Biol Chem. 2001 Mar 16;276(11):7836-42
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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