Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pla2g1btm1Dyh
Name:	phospholipase A2, group IB, pancreas; targeted mutation 1, David Y Hui
MGI ID:	MGI:2445572
Synonyms:	PLA2(-)
Gene:	Pla2g1b  Location: Chr5:115604321-115612781 bp, + strand  Genetic Position: Chr5, 56.1 cM, cytoband F1-G1.1
Alliance:	Pla2g1btm1Dyh page

Germline Transmission:	Earliest citation of germline transmission: J:68430
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 2 was disrupted by the insertion of a neomycin selection cassette. Neither protein nor phospholipid hydrolytic activity was detected in homozygous mutant mice by Western blot analysis or biochemical assay of pancreatic extracts. (J:68430)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pla2g1b Mutation:	15 strains or lines available

Original:	J:68430 Richmond BL, et al., Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A(2)-deficient mice. Gastroenterology. 2001 Apr;120(5):1193-202
All:	5 reference(s)