Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Gja5tm1Paul
Name:	gap junction protein, alpha 5; targeted mutation 1, David L Paul
MGI ID:	MGI:2445466
Synonyms:	Cx40-
Gene:	Gja5  Location: Chr3:96939718-96960950 bp, + strand  Genetic Position: Chr3, 42.04 cM
Alliance:	Gja5tm1Paul page

Germline Transmission:	Earliest citation of germline transmission: J:46430
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The single coding exon of the gene was deleted and replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by immunohistochemical analysis of frozen heart sections from homozygous mutant animals. (J:46430)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	36 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gja5 Mutation:	18 strains or lines available

Original:	J:46430 Simon AM, et al., Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr Biol. 1998 Feb 26;8(5):295-8
All:	29 reference(s)