Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Pitx2tm1Sac
Name:	paired-like homeodomain transcription factor 2; targeted mutation 1, Sally A Camper
MGI ID:	MGI:1857844
Synonyms:	Pitx2-, Pitx2neo
Gene:	Pitx2  Location: Chr3:128993527-129013240 bp, + strand  Genetic Position: Chr3, 57.84 cM
Alliance:	Pitx2tm1Sac page

Germline Transmission:	Earliest citation of germline transmission: J:51160
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, Hypomorph) Mutation:    Insertion   Mutation details: Gene targeting was performed with a vector engineered to contain a loxP site downstream from exon 4 and a floxed neomycin cassette upstream of exon 4. This allele is a demonstrated hypomorph. (J:51160)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:	38 strains or lines available

Original:	J:51160 Gage PJ, et al., Dosage requirement of Pitx2 for development of multiple organs. Development. 1999 Oct;126(20):4643-51
All:	14 reference(s)