About   Help   FAQ
Mgat3tm1Pst
Targeted Allele Detail
Summary
Symbol: Mgat3tm1Pst
Name: mannoside acetylglucosaminyltransferase 3; targeted mutation 1, Pamela Stanley
MGI ID: MGI:1857829
Synonyms: Mgat3neo, Mgat3T37
Gene: Mgat3  Location: Chr15:80057922-80099720 bp, + strand  Genetic Position: Chr15, 37.85 cM, cytoband E
Alliance: Mgat3tm1Pst page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48441
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into the coding region of the gene, disrupting it. Northern blots of brain and kidney RNA from homozygous mutant mice showed a lack of endogenous transcript for the targeted gene. (J:48441)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Mgat3tm1Pst
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mgat3 Mutation:  32 strains or lines available
References
Original:  J:48441 Bhaumik M, et al., Progression of hepatic neoplasms is severely retarded in mice lacking the bisecting N-acetylglucosamine on N-glycans: evidence for a glycoprotein factor that facilitates hepatic tumor progression. Cancer Res. 1998 Jul 1;58(13):2881-7
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory