Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol: Zeb1tm2Yhi Name: zinc finger E-box binding homeobox 1; targeted mutation 2, Yujiro Higashi MGI ID: MGI:1857799 Synonyms: deltaEF1-, deltaEF1null(lacZ), Tcf8-, Zeb1tm2Yhi, Zfhx1a- Gene: Zeb1  Location: Chr18:5591860-5775467 bp, + strand  Genetic Position: Chr18, 4.42 cM Alliance: Zeb1tm2Yhi page

Inner ear abnormality in Zeb1tm2Yhi/Zeb1tm2Yhi and Zeb1tm2Yhi/Zeb1Tw mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:45575
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A lacZ-neo cassette including termination signals replaced exon 1. The targeted allele encodes a fusion protein that lacks the DNA-binding and homeodomains functionally essential to the endogenous protein. Northern blot analysis showed an absence of normal transcript in homozygous mutant embryos. The expression pattern of beta-galactosidase largely resembled that of the endogenous gene, with the noted exception of expression in the notochord. (J:45575)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	362 assay results
In Structures Affected by this Mutation:	40 anatomical structure(s)

List all tumor models in MMHCdb carrying Zeb1tm2Yhi

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zeb1 Mutation:	65 strains or lines available

Original:	J:45575 Takagi T, et al., DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages. Development. 1998 Jan;125(1):21-31
All:	27 reference(s)