Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Shhtm1Chg
Name:	sonic hedgehog; targeted mutation 1, Chin Chiang
MGI ID:	MGI:1857796
Synonyms:	Shh-, Shhnull
Gene:	Shh  Location: Chr5:28661838-28672099 bp, - strand  Genetic Position: Chr5, 14.39 cM
Alliance:	Shhtm1Chg page

Germline Transmission:	Earliest citation of germline transmission: J:35802
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK neomycin cassette replaced exon 2 and portions of the flanking intronic sequences in the Shh gene. (J:35802) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	799 assay results
In Structures Affected by this Mutation:	47 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shh Mutation:	45 strains or lines available

Original:	J:35802 Chiang C, et al., Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 1996 Oct 3;383(6599):407-13
All:	169 reference(s)