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Gsra1Neu
Chemically induced Allele Detail
Summary
Symbol: Gsra1Neu
Name: glutathione reductase; glutathione reductase 1, Neuherberg
MGI ID: MGI:1857772
Synonyms: GR 180, Gr1a1Neu, Gsrnull
Gene: Gsr  Location: Chr8:34143266-34188190 bp, + strand  Genetic Position: Chr8, 20.69 cM
Alliance: Gsra1Neu page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Chemically induced (other) (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe mutation is a small deletion that removes nucleotides 10840 through 23627 of the gene and functionally deletes exons 2 through 5. In addition, the deletion produces a frame shift in exon 6 and introduces a stop codon in exon 7 that prevents translation of the remainder of the protein. (J:103511)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
1 RNA-Seq or microarray experiment(s)
Tumor Data
List all tumor models in MMHCdb carrying Gsra1Neu
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gsr Mutation:  51 strains or lines available
Notes
Induced by isopropyl methanesulphonate (iPMS)
References
Original:  J:54306 Pretsch W, Glutathione reductase activity deficiency in homozygous Gr1a1Neu mice does not cause haemolytic anaemia. Genet Res. 1999 Feb;73(1):1-5
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory