Tlr4<lps-n> Spontaneous Allele Detail MGI Mouse (MGI:1857731)

Tlr4^lps-n
Spontaneous Allele Detail

Summary

Symbol:	Tlr4^lps-n
Name:	toll-like receptor 4; normal lipopolysaccharide response
MGI ID:	MGI:1857731
Synonyms:	TLR⁺, TLR4^s
Gene:	Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
Alliance:	Tlr4^lps-n page

Mutation
origin

Strain of Origin:

C3H/HeN

Mutation
description

Allele Type:		Spontaneous
Mutation:		Undefined
		Mutation details: The allele for normal response to lipopolysaccharides, Lpsⁿ, occurs in most C3H substrains and in other inbred strains. (J:51522)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:	90 strains or lines available

Notes

A/J, C3H/HeN, and C3H/HePas mice carry this allele. Various combinations of Lps-associated traits have been followed in crosses between C3H/HeJ and other C3H substrains, and the traits have in all cases segregated together (J:30692, J:5557, J:5593, J:5938). Some of the traits show dominance of the Tlr4^lps-n allele; others, including Tlr4^Lps-d, show codominance.

References

Original:	J:5721 Dumont F, et al., Electrokinetic properties of splenic lymphocytes from the low-lipopolysaccharide responder C3H/Hej mice. Folia Biol (Praha). 1976;12(3):145-50
All:	37 reference(s)

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