Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol: Smad4tm1Cxd Name: SMAD family member 4; targeted mutation 1, Chu-Xia Deng MGI ID: MGI:1857698 Synonyms: S4-, smad4-, Smad4ex8 Gene: Smad4  Location: Chr18:73772080-73836851 bp, - strand  Genetic Position: Chr18, 49.51 cM Alliance: Smad4tm1Cxd page

Morphological and molecular analyses of Smad4tm1Cxd/Smad4tm1Cxd embryos Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:46852
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 8 of the gene, which resulted in a 198 amino acid truncation of the protein's C-terminal end. (J:46852)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

List all tumor models in MMHCdb carrying Smad4tm1Cxd

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad4 Mutation:	43 strains or lines available

Original:	J:46852 Yang X, et al., The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3667-72
All:	11 reference(s)