Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pitx1tm1Jdr
Name:	paired-like homeodomain transcription factor 1; targeted mutation 1, Jaques Drouin
MGI ID:	MGI:1857659
Synonyms:	Pitxtm1, Ptx1-
Gene:	Pitx1  Location: Chr13:55972864-55984005 bp, - strand  Genetic Position: Chr13, 30.06 cM
Alliance:	Pitx1tm1Jdr page

Germline Transmission:	Earliest citation of germline transmission: J:52671
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 of this gene containing a homeodomain was replaced with a PGKneo-derived cassette via homologous recombination. Gene expression was not detected in Northern blot of mandibles from homozygous mutant embryos. (J:52671)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	76 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	22 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pitx1 Mutation:	10 strains or lines available

Original:	J:52671 Lanctot C, et al., Hindlimb patterning and mandible development require the Ptx1 gene. Development. 1999 May;126(9):1805-10
All:	9 reference(s)