Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	MitfMi-b
Name:	melanogenesis associated transcription factor; microphthalmia brownish
MGI ID:	MGI:1856086
Gene:	Mitf  Location: Chr6:97784013-97998310 bp, + strand  Genetic Position: Chr6, 45.05 cM
Alliance:	MitfMi-b page

Strain of Origin:

T stock x (101/Rl x C3H/Rl)F1

Allele Type:    Spontaneous Mutation:    Single point mutation   Mutation details: G-to-A transition leading to a p.Gly244Glu substitution in the encoded protein. This amino acid is in helix 2 of the HLH dimerization domain. (J:37067) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mitf Mutation:	72 strains or lines available

Original:	J:15061 Larsen M, Microphthalmia-brownish, Mib. Mouse News Lett. 1966;34:41
All:	5 reference(s)