Raratm1Ipc
Targeted Allele Detail
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| Symbol: |
Raratm1Ipc |
| Name: |
retinoic acid receptor, alpha; targeted mutation 1, Pierre Chambon |
| MGI ID: |
MGI:1857622 |
| Synonyms: |
Aalpha, Rara-, RARalpha- |
| Gene: |
Rara Location: Chr11:98818644-98865768 bp, + strand Genetic Position: Chr11, 62.76 cM, cytoband D-E1
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| Alliance: |
Raratm1Ipc page
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Degenerative lesions in testes of 4 to 5 month old Raratm1Ipc/Raratm1Ipc mice
Show the 1 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:13574
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| Parent Cell Line: |
D3 (ES Cell)
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| Strain of Origin: |
129S2/SvPas
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: A neomycin cassette was inserted into exon 8, which encodes the common receptor region B. This disruption is predicted to prevent the synthesis of all Rara isoforms. RNAase protection analysis of homozygous E13.5 embryos failed to detect wild type RNA transcripts and immunoblot analysis failed to detect protein in in extracts from homozygous E13.5 embryos.
(J:13574)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Rara Mutation: |
79 strains or lines available
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| Original: |
J:13574 Lufkin T, et al., High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7225-9 |
| All: |
32 reference(s) |
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Analysis Tools
