Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Zeb1tm1Yhi Name: zinc finger E-box binding homeobox 1; targeted mutation 1, Yujiro Higashi MGI ID: MGI:1857515 Synonyms: deltaEF1deltaC727 Gene: Zeb1  Location: Chr18:5591860-5775467 bp, + strand  Genetic Position: Chr18, 4.42 cM Alliance: Zeb1tm1Yhi page

Abnormal thymus architecture in Zeb1tm1Yhi/Zeb1tm1Yhi mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:39865
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The insertion of a neomycin selection cassette into exon 6 introduced a stop codon that precludes translation of the essential zinc finger DNA-binding domain. Northern blot analysis of total embryonic RNA showed the presence of longer transcripts, resulting from the insertion of neo. Western blot analysis using an anti-serum directed against the amino terminus of the encoded protein confirmed the presence of a truncated protein in extracts from homozygous mutant embryos. (J:39865)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Zeb1 Mutation:	65 strains or lines available

Original:	J:39865 Higashi Y, et al., Impairment of T cell development in deltaEF1 mutant mice. J Exp Med. 1997 Apr 21;185(8):1467-79
All:	6 reference(s)