Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tlx2tm1Ut
Name:	T cell leukemia, homeobox 2; targeted mutation 1, University of Toronto
MGI ID:	MGI:1857514
Synonyms:	Tlx-2-
Gene:	Tlx2  Location: Chr6:83045306-83047206 bp, - strand  Genetic Position: Chr6, 35.94 cM, cytoband C3-D1
Alliance:	Tlx2tm1Ut page

Germline Transmission:	Earliest citation of germline transmission: J:48372
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A lacZ sequence and neomycin resistance cassette replaced most of the first exon, starting at the initiation codon. (J:48372)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlx2 Mutation:	12 strains or lines available

Original:	J:48372 Tang SJ, et al., The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development. 1998 May;125(10):1877-87
All:	1 reference(s)