Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Otx2tm2Sla
Name:	orthodenticle homeobox 2; targeted mutation 2, Siew Lan Ang
MGI ID:	MGI:1857513
Synonyms:	Otx2hygro
Gene:	Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance:	Otx2tm2Sla page

Germline Transmission:	Earliest citation of germline transmission: J:46641
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A hygromycin resistance cassette replaced the first and second exons of the gene, including the translation start site and and most of the sequences encoding the homeodomain. (J:46641)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:	50 strains or lines available

Original:	J:46641 Rhinn M, et al., Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. Development. 1998 Mar;125(5):845-56
All:	2 reference(s)