Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ucp1tm1Kz
Name:	uncoupling protein 1 (mitochondrial, proton carrier); targeted mutation 1, Leslie Kozak
MGI ID:	MGI:1857471
Synonyms:	Ucp1-, Ucptm1
Gene:	Ucp1  Location: Chr8:84016981-84025081 bp, + strand  Genetic Position: Chr8, 39.65 cM
Alliance:	Ucp1tm1Kz page

Germline Transmission:	Earliest citation of germline transmission: J:40053
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: All of exon 2 and a portion of exon 3 were replaced by a neomycin selection cassette. The deleted region encoded an essential transmembrane domain. Transcript was undetected in homozygous mutant mice via Northern blot analysis. Western blot analysis confirmed the absence of encoded protein. (J:40053)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ucp1 Mutation:	46 strains or lines available

Original:	J:40053 Enerback S, et al., Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese [see comments]. Nature. 1997 May 1;387(6628):90-4
All:	137 reference(s)